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Questions and AnswersQuestion No.: 14349 Submitted By: Phil A Submitted on: March 3, 2002 Subject: lithium orotate Question: Dear Dr Cinque, I have read recently of the latest findings in regard to the action of Lithium on the brain, i.e. that it inhibits tau protein tangles, protects neurons from glutamate toxicity, actually increases grey matter after 4 weeks (by 3%) and, of course, evens out mood swings. All of this is making it a prime candidate for an Alzheimer's treatment. As the orotate, it is said to be without side-effects. I have ordered some (from VRP - I didn't know of your site then!)to try it for my mother who has AD. Do you have any comments to add in this regard, please? Dr. Cinque's Answer: I have discussed lithium orotate with Dr. Ward Dean, and I know he is very enthused about it and regards it as a superior form of lithium. Here is what he wrote in the July 1999 VRP Newsletter: "The lithium salt of orotic acid (lithium orotate) improves the specific effects of lithium many-fold by increasing lithium bio-utilization. The orotates transport the lithium to the membranes of mitochondria, lysosomes and the glia cells. Lithium orotate stabilizes the lysosomal membranes and prevents the enzyme reactions that are responsible for the sodium depletion and dehydration effects of other lithium salts. Because of the superior bioavailability of lithium orotate, the therapeutic dosage is much less than prescription forms of lithium. For example, in cases of severe depression, the therapeutic dosage of lithium orotate is 150 mg/day. This is compared to 900-1800 mg of the prescription forms. In this dosage range of lithium orotate, there are no adverse lithium side reactions and no need for monitoring blood serum measurements." You can read the whole article by going to www.vrp.com. |
