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Fosamex linked to more atrial fib Women who have used Fosamax are nearly twice as likely to develop the most common kind of chronically irregular heartbeat, known as atrial fibrillation, than are those who have never used it, according to research from Group Health and the University of Washington. It was published in the April 28 edition of the Archives of Internal Medicine. Merck makes and markets Fosamax- the most widely used drug treatment for the bone-thinning disease osteoporosis, explained study leader Susan Heckbert, MD, PhD, MPH, professor of epidemiology and scientific investigator in the Cardiovascular Health Research Unit at the University of Washington. The FDA just approved the first generic versions of Fosamex (known generically as alendronate) in February. "We studied more than 700 female Group Health patients whose atrial fibrillation was first detected during a three-year period," said Dr. Heckbert. She and her colleagues compared those women to over 900 randomly selected female Group Health members matched on age and high blood pressure to serve as controls. "Having ever used alendronate was associated with an 86 percent higher risk of newly detected atrial fibrillation compared with never having used the drug," said Dr. Heckbert, who is also an affiliate investigator at the Group Health Center for Health Studies. Osteoporosis mostly affects older women and can set the stage for fractures that can impair the quality of their lives, said Dr. Heckbert. "Careful judgment is required to weigh the risks and benefits of any medication for any individual patient," she added. "For most women at high risk of fracture, alendronate’s benefit of reducing fractures will outweigh the risk of atrial fibrillation." However, said Dr. Heckbert, "women who are at high risk of fractures but also have risk factors for atrial fibrillation—such as heart failure, diabetes, or coronary disease—might want to discuss alternatives to alendronate with their health care providers." Other medications that can lower the risk of fractures include estrogen, she said. But the Women’s Health Initiative, on which she has also served as an investigator, showed other heart risks from hormone therapy combining estrogen with progesterone. The National Heart, Lung, and Blood Institute funds Dr. Heckbert’s Atrial Fibrillation Study, which collects data on all Group Health patients as they are first diagnosed with atrial fibrillation. The study aims to find new factors that raise the risk of developing this quivering of the heart’s upper chambers (atria). About one in 100 people—and nearly nine in 100 people over age 80—have atrial fibrillation, said Dr. Heckbert. In many cases, atrial fibrillation has no symptoms, and it isn’t necessarily life threatening. But it can cause palpitations, fainting, fatigue, or congestive heart failure. Atrial fibrillation can also make blood pool—and sometimes clot—in the atria, said Dr. Heckbert. When parts of clots break off and leave the atria, they can lead to embolic strokes, as happens in over 70,000 Americans a year. That’s why atrial fibrillation is often treated with the anticoagulant warfarin. Other results from her study have suggested that maintaining a healthy body weight may help protect people from atrial fibrillation. "This study will help medical teams better inform their patients about the risks associated with Fosamax, helping us make the best treatment decisions for managing osteoporosis," commented Christine Himes Fordyce, MD, a Group Health family practitioner. "Now with this increased understanding of potential irregular heartbeats, both physicians and their patients should be alert to any problems, report them immediately, and treat them appropriately." Dr. Cinque's comments: The basis by which Fosamex works is that it poisons certain bone cells called osteoclasts. But the purpose of osteoclasts is not to give you osteoporosis. Bone is a very dynamic tissue, which means that it is constantly being remolded and remade in responses to the changing stresses being placed upon it. Osteoclasts have a normal role to play throughout all phases of life, which involves adapting to changes in mechanical stress and also facilitating the changing vascular requirements of bone, and that is why it is perilous to undermine osteoclasts. For instance, with biophosphonate drugs like Fosamex, there is a risk of osteonecrosis, or bone death, particularly of the jaw, but also presumably of the hip, knee, and shoulders. But the plain truth is that any time a drug works by poisoning something, it's playing with fire because it's very hard to limit the effects of poisoning to just one kind of cell. Look at what happens with cancer chemotherapy. They try very hard to design drugs that will poison cancer cells and not normal cells, but it's tough to do, and it never works out perfectly that way. The healthy cells invariably suffer to some extent. So, if I were a woman, and even in being a man, I would never consider taking Foxamex or any other biophosphonate drugs. I would only resort to non-poisoning measures to build and maintain my bones. Obviously, the foundation is lifestyle: diet, exercise, sun exposure, and adequate sleep. But I would also take supplemental Vitamin D and Vitamin K2. Calcium supplementation I would do, but only very cautiously because of new concerns that calcium provokes heart disease. After all, they don't call it "hardening of the arteries" for nothing. Calcium is the hard thing that makes arteries hard. Right now, I'm 57, and the only thing I am doing to monitor the condition of my bones is keeping track of my height. And so far, I'm not losing any, and I feel good about that. But whether for myself or others, I shudder at the thought of biophosphonate drugs. E-mail to a friend Next Article |
