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· · Too much alcohol damages heart and arteries

Heavy drinking causes high blood pressure, stiff arteries and rigid heart muscles in men and enlarged hearts in women, boosting their risk of having heart attacks and strokes, researchers said on Wednesday.

They defined heavy drinking as 21 or more drinks a week for men and 14 or more per week for women.

"We definitely see quite a deleterious effect," said Dr. Azra Mahmud of St. James Hospital in Dublin, who presented her findings at a meeting of the American Society of Hypertension in New Orleans. "The most worrisome aspect is in women. It has a direct toxic effect," Mahmud said in a telephone interview. "Basically, women are not able to cope with high alcohol consumption. It is going directly to the heart and damaging it."

Once a heart becomes enlarged -- a sign it has been overtaxed -- it is difficult to reverse. Mahmud said prior studies have suggested that people with enlarged hearts are five to six times more likely to have heart attacks.

Moderate drinking has been shown in many studies to have heart benefits. But heavy drinking counteracts these benefits and can cause serious harm, she said.

In her study, Mahmud and colleagues looked at whether high alcohol consumption resulted in structural changes in the heart and arteries of people already at risk for high blood pressure. Mahmud studied 200 men and women with an average age of 46 who were referred to her hypertension clinic but were not being treated for high blood pressure. People in the study were put into three categories: nondrinkers, moderate drinkers (fewer than 21 drinks a week for men and fewer than 14 a week for women), and heavy drinkers (21 or more drinks a week for men and 14 or more weekly for women).

About 20 percent of the women fell into the heavy drinker category and nearly 40 percent of the men were heavy drinkers, she said. The researchers measured the heart muscle and assessed stiffness of arteries and blood pressure inside the aorta. They found men who were the heaviest drinkers were the most likely to have high blood pressure and stiffening of the arteries and heart muscle. Women who were the heaviest drinkers were most likely to have enlarged hearts.

Mahmud said heavy drinking seemed to accelerate the effects of high blood pressure in men, and cause a direct toxic effect to heart tissue in women. The findings were above what would be expected for people of the same age with high blood pressure.

Heart disease is the No. 1 killer globally. According to the World Health Organization, heart disease killed 17.5 million people in 2005, and that number is expected to rise to nearly 20 million by 2015.

Dr. Cinque's comments: 3 drinks are decidedly bad for you; 2 drinks are decidedly good, unless you are a woman, in which case 2 drinks are decidedly bad, and 1 drink is decidedly good. That's the official dogma, and it has been for a long time. But how likely is it to be true? It suggests a very sharp non-linearity in the effects of alcohol. But there is plenty of evidence to suggest that the effects of alcohol are linear. For instance, even at the lowest level of consumption (1 drink), impairment of the nervous system takes place which can be measured, such as discoordination and delayed reaction time, and it is in line with the more profound changes that take place with higher levels of consumption. The journal Aviation, Space, and Environmental Medicine reported in 1994 that even at blood alcohol levels as low as .1 percent (which is 8 times lower than the level of legal intoxication), impairment of visual-spatial skills (for driving or flying) was detected. Although epidemiological studies are repeatedly used to establish health benefits from alcohol, I don't buy any of it. A controlled, randomized study of alcohol consumption among humans has never been done. A recent study tried to claim that alcohol protects and preserves the bones, and unlike with the heart, there isn't even a theoretical basis for believing that. The religion of alcohol as health food is getting really whacky.

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