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· · Low Vitamin D boosts depression risk in seniors

Older people with low blood levels of vitamin D and high blood levels of parathyroid hormone are more likely to be depressed, Dutch researchers report.

But it remains unclear whether these abnormalities are a cause or a consequence of depression, say Dr. Witte J. G. Hoogendijk and colleagues from Vrije Universiteit in Amsterdam.

Past studies have linked altered levels of vitamin D and parathyroid hormone with depression, but the relationship "has never been studied systematically," say Hoogendijk and colleagues. To investigate, they looked at 1,282 men and women aged 65 to 95 years participating in a long-term study of aging.

Nearly 40 percent of the men and 57 percent of women had low levels of vitamin D in their blood.

Among the 169 people found by self-report and diagnostic interviews to be suffering from minor depression, as well as the 26 with major depressive disorder, vitamin D levels were 14 percent lower than for people who were free from depression, the researchers found.

And blood levels of parathyroid hormone, which increase with vitamin D deficiency, were 5 percent higher in people with minor depression and 33 percent higher in those with major depression, relative to levels seen in seniors without depression.

There are a number of plausible ways that low vitamin D levels could influence mood, the researchers note, given that the vitamin plays a role in several neurological and hormonal processes. If vitamin D deficiency is a cause rather than a result of depression, they add, this suggests supplementation with the vitamin and increased exposure to sunlight could help treat depression.

Long-term studies with repeated assessments are needed to answer the question of whether low vitamin D is a cause or an effect of depression, and likewise with increased parathyroid hormone levels, which are a consequence of low Vitamin D status, the researchers conclude.

SOURCE: Archives of General Psychiatry, May 2008

Dr. Cinque's comments: We all know intuitively that sunshine lifts our mood, but some people are more sensitive to it than others. I am particularly sensitive to it, and that's why I live in Central Texas. I couldn't live in Seattle or Boston and be happy- there's just no way. Partly it relates to my lifestyle because I enjoy being active outdoors, hiking, biking, and swimming. And, I also like to seek out fresh local foods, and Texas is pretty good that way all yearround, including the wintertime when there are winter vegetables and citrus fruits available. But even aside from all that, there is some indefinable effect from sunshine that makes me feel good. And if I ever leave Texas, it will be for a more sun-drenched place. And speaking of that, here is a list of major cities in the USA ranked by their number of sunny days per year. As expected, the Southwest and California finished high on the list, but surprisingly, Florida and Hawaii did not. Keep in mind that this refers to totally clear sunny days and does not include partly sunny days. The list was compiled by the National Oceanic and Atmospheric Administration (NOAA), National Climatic Data Center.

YUMA,AZ 242
PHOENIX,AZ 211
LAS VEGAS,NV 210
BISHOP,CA 201
FRESNO,CA 194
EL PASO,TX 193
TUCSON,AZ 193
BAKERSFIELD,CA 191
SACRAMENTO,CA 188
LOS ANGELES,CA 186
STOCKTON,CA 184
WINSLOW,AZ 177
SANTA MARIA,CA 176
BLUE CANYON,CA 174
REDDING,CA 172
ROSWELL,NM 168
ALBUQUERQUE,NM 167
MIDLAND-ODESSA,TX 165
MOUNT SHASTA, CA 164
CLAYTON,NM 162
FLAGSTAFF,AZ 162
LUBBOCK,TX 160
SAN FRANCISCO AP,CA 160
LONG BEACH,CA 159
RENO,NV 158
AMARILLO,TX 157
SAN ANGELO,TX 154
MILFORD,UT 151
WICHITA FALLS,TX 151
ABILENE,TX 149
ALAMOSA,CO 148
SAN DIEGO,CA 146
GOODLAND,KS 143
OKLAHOMA CITY,OK 139
PUEBLO,CO 139
WINNEMUCCA,NV 138
DODGE CITY,KS 137
GRAND JUNCTION,CO 136
DALLAS-FORT WORTH,TX 135
CONCORDIA,KS 131
ELY,NV 130
KAHULUI,HI 131
ELKO,NV 130
WACO,TX 130
APALACHICOLA,FL 128
WICHITA,KS 128
COLORADO SPRINGS,CO 127
TULSA,OK 127
SEXTON SUMMIT,OR 126
SALT LAKE CITY,UT 125
FORT SMITH,AR 123
GRAND ISLAND,NE 123
VALENTINE,NE 123
DEL RIO,TX 121
GREENVILLE-SPARTANBURG SC 121
WAKE ISLAND,PC 121
BOISE,ID 120
BURNS,OR 120
KANSAS CITY,MO 120
LITTLE ROCK,AR 119
TUPELO,MS 119
MEMPHIS,TN 118
LINCOLN,NE 117
MEDFORD,OR 117
NORFOLK,NE 117
AUSTIN,TX 115
COLUMBIA,SC 115
DENVER,CO 115
NORTH PLATTE,NE 115
SCOTTSBLUFF,NE 115
SPRINGFIELD,MO 115
LANDER,WY 114
SHREVEPORT,LA 114
TOPEKA,KS 114
ATHENS,GA 113
CAIRO,IL 113
AUGUSTA,GA 112
LYNCHBURG,VA 112
MACON,GA 112
JACKSON,MS 111
OMAHA NE 111
RALEIGH,NC 111
RAPID CITY,SD 111
WILMINGTON,NC 111
ATLANTA,GA 110
COLUMBUS,GA 110
OMAHA (NORTH),NE 110
CAPE HATTERAS,NC 109
CHARLOTTE,NC 109
GREENSBORO-WNSTN-SALM, NC 109
OAK RIDGE,TN 109
YAKIMA,WA 109
MERIDIAN,MS 108
CASPER,WY 107


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